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International Journal of Advanced Technology and Engineering Exploration (IJATEE)

ISSN (Print):2394-5443    ISSN (Online):2394-7454
Volume-9 Issue-97 December-2022
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Paper Title : Evaluation of polycaprolactone/carboxymethylcellulose scaffolds using hyperelastic model
Author Name : Noppadol Sriputtha, Fasai Wiwatwongwana and Nattawit Promma
Abstract :

Tissue engineering is an interesting field. The tissue engineering scaffold allows the delivery of cells and growth factors to the damaged part of the body to allow for the regeneration of tissue. This work aimed to evaluate polycaprolactone (PCL) blended with carboxymethylcellulose (CMC) composite scaffolds. The porous scaffolds were created using the salt leaching process. An experimental technique was used to characterize the mechanical characteristics of the scaffolds. We evaluated the modeling by describing the stress-strain behavior of the scaffolds using the neo-Hookean model. The shear modulus of the polycaprolactone scaffold containing 2, 11, 15.5, and 20% CMC was 0.074, 0.037, 0.034, and 0.085 megapascal (MPa), respectively. A scaffold with a PCL/CMC ratio of 93.5/6.5 had the highest average shear modulus of 0.245 MPa when compared to other mixed scaffolds. There was a significant difference when compared to a pure polycaprolactone scaffold. The result could provide excellent conditions for creating scaffolds for use in cell transplantation and culture.
Keywords : Polycaprolactone, Carboxymethylcellulose, Compressive modulus, Shear modulus, Neo-hookean model.
Cite this article : Sriputtha N, Wiwatwongwana F, Promma N. Evaluation of polycaprolactone/carboxymethylcellulose scaffolds using hyperelastic model . International Journal of Advanced Technology and Engineering Exploration. 2022; 9(97):1718-1729. DOI:10.19101/IJATEE.2021.876118.
References :
[1]Colonna M. Skin function for human CD1a-reactive T cells. Nature Immunology. 2010; 11(12):1079-80.
[Crossref] [Google Scholar]
[2]Laurencin CT, Nair LS. Nanotechnology and tissue engineering: the scaffold. CRC Press; 2008.
[Crossref] [Google Scholar]
[3]Kang NU, Hong MW, Kim YY, Cho YS, Lee SJ. Development of a powder extruder system for dual-pore tissue-engineering scaffold fabrication. Journal of Bionic Engineering. 2019; 16(4):686-95.
[Crossref] [Google Scholar]
[4]Sriputtha N, Wiwatwongwana F, Promma N. Investigation of polycaprolactone/carboxymethyl cellulose scaffolds by mechanical and thermal analysis. Engineering, Technology & Applied Science Research. 2022; 12(1):8175-9.
[Crossref] [Google Scholar]
[5]Donate R, Monzón M, Alemán-domínguez ME. Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties. e-Polymers. 2020; 20(1):571-99.
[Crossref] [Google Scholar]
[6]Todros S, Todesco M, Bagno A. Biomaterials and their biomedical applications: from replacement to regeneration. Processes. 2021; 9(11):1-20.
[Crossref] [Google Scholar]
[7]Sabzi E, Abbasi F, Ghaleh H. Interconnected porous nanofibrous gelatin scaffolds prepared via a combined thermally induced phase separation/particulate leaching method. Journal of Biomaterials Science, Polymer Edition. 2020; 32(4):488-503.
[Crossref] [Google Scholar]
[8]Jing X, Mi HY, Turng LS. Comparison between PCL/hydroxyapatite (HA) and PCL/halloysite nanotube (HNT) composite scaffolds prepared by co-extrusion and gas foaming. Materials Science and Engineering: C. 2017; 72:53-61.
[Crossref] [Google Scholar]
[9]Åkerlund E, Diez-escudero A, Grzeszczak A, Persson C. The effect of PCL addition on 3d-printable PLA/HA composite filaments for the treatment of bone defects. Polymers. 2022; 14(16):1-17.
[Crossref] [Google Scholar]
[10]Kurniawan D, Nor FM, Lee HY, Lim JY. Elastic properties of polycaprolactone at small strains are significantly affected by strain rate and temperature. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2011; 225(10):1015-20.
[Crossref] [Google Scholar]
[11]Dwivedi R, Kumar S, Pandey R, Mahajan A, Nandana D, Katti DS, et al. Polycaprolactone as biomaterial for bone scaffolds: review of literature. Journal of Oral Biology and Craniofacial Research. 2020; 10(1):381-8.
[Crossref] [Google Scholar]
[12]Gómez-lizárraga KK, Flores-morales C, Del prado-audelo ML, Álvarez-pérez MA, Piña-barba MC, Escobedo C. Polycaprolactone-and polycaprolactone/ceramic-based 3D-bioplotted porous scaffolds for bone regeneration: a comparative study. Materials Science and Engineering: C. 2017; 79:326-35.
[Crossref] [Google Scholar]
[13]Mondal D, Griffith M, Venkatraman SS. Polycaprolactone-based biomaterials for tissue engineering and drug delivery: current scenario and challenges. International Journal of Polymeric Materials and Polymeric Biomaterials. 2016; 65(5):255-65.
[Crossref] [Google Scholar]
[14]Wachirahuttapong S, Thongpin C, Sombatsompop N. Effect of PCL and compatibility contents on the morphology, crystallization and mechanical properties of PLA/PCL blends. Energy Procedia. 2016; 89:198-206.
[Crossref] [Google Scholar]
[15]Kondiah PP, Rants’o TA, Mdanda S, Mohlomi LM, Choonara YE. A poly (caprolactone)-cellulose nanocomposite hydrogel for transdermal delivery of hydrocortisone in treating psoriasis vulgaris. Polymers. 2022; 14(13):1-23.
[Crossref] [Google Scholar]
[16]Rahman MS, Hasan MS, Nitai AS, Nam S, Karmakar AK, Ahsan MS, et al. Recent developments of carboxymethyl cellulose. Polymers. 2021; 13(8):1-48.
[Crossref] [Google Scholar]
[17]Zennifer A, Senthilvelan P, Sethuraman S, Sundaramurthi D. Key advances of carboxymethyl cellulose in tissue engineering & 3D bioprinting applications. Carbohydrate Polymers. 2021; 256:1-18.
[Crossref] [Google Scholar]
[18]Gaihre B, Jayasuriya AC. Fabrication and characterization of carboxymethyl cellulose novel microparticles for bone tissue engineering. Materials Science and Engineering: C. 2016; 69:733-43.
[Crossref] [Google Scholar]
[19]Qi P, Ohba S, Hara Y, Fuke M, Ogawa T, Ohta S, et al. Fabrication of calcium phosphate-loaded carboxymethyl cellulose non-woven sheets for bone regeneration. Carbohydrate Polymers. 2018; 189:322-30.
[Crossref] [Google Scholar]
[20]Fan L, Peng M, Zhou X, Wu H, Hu J, Xie W, et al. Modification of carboxymethyl cellulose grafted with collagen peptide and its antioxidant activity. Carbohydrate Polymers. 2014; 112:32-8.
[Crossref] [Google Scholar]
[21]Biswal DR, Singh RP. Characterisation of carboxymethyl cellulose and polyacrylamide graft copolymer. Carbohydrate Polymers. 2004; 57(4):379-87.
[Crossref] [Google Scholar]
[22]Diaz-gomez L, Gonzalez-prada I, Millan R, Da SA, Bugallo-casal A, Campos F, et al. 3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing. Carbohydrate Polymers. 2022; 278:1-12.
[Crossref] [Google Scholar]
[23]Cheng J, Zhang LT. A general approach to derive stress and elasticity tensors for hyperelastic isotropic and anisotropic biomaterials. International Journal of Computational Methods. 2018; 15(4):1-40.
[Crossref] [Google Scholar]
[24]Wiwatwongwana F, Chaijit S. Mechanical properties analysis of gelatin/carboxymethylcellulose scaffolds. International Journal of Materials, Mechanics and Manufacturing. 2019; 7(3):138-43.
[Crossref] [Google Scholar]
[25]Holzapfel GA. Nonlinear solid mechanics: a continuum approach for engineering science. Meccanica. 2002; 37(4):489-90.
[Google Scholar]
[26]Dong X, Duan Z. Comparative study on the sealing performance of packer rubber based on elastic and hyperelastic analyses using various constitutive models. Materials Research Express. 2022; 9(7):1-13.
[Crossref] [Google Scholar]
[27]Anssari-benam A, Bucchi A, Saccomandi G. Modelling the inflation and elastic instabilities of rubber-like spherical and cylindrical shells using a new generalised neo-Hookean strain energy function. Journal of Elasticity. 2022; 151(1):15-45.
[Crossref] [Google Scholar]
[28]Simon PFJ, Cuadrado SÓ, Marques EA, Sánchez LM, Da SLF. Mechanical characterisation and comparison of hyperelastic‎ adhesives: modelling and experimental validation. Journal of Applied and Computational Mechanics. 2022; 8(1):359-69.
[Crossref] [Google Scholar]
[29]Kar P, Myneni M, Tůma K, Rajagopal KR, Benjamin CC. Axial pulling of a neo-Hookean fiber embedded in a generalized neo-Hookean matrix. International Journal of Non-Linear Mechanics. 2022; 148:1-10.
[Google Scholar]
[30]Chen Y, Guo W, Yang P, Zhao J, Guo Z, Dong L, et al. Constitutive modeling of neo-Hookean materials with spherical voids in finite deformation. Extreme Mechanics Letters. 2018; 24:47-57.
[Crossref] [Google Scholar]
[31]Raheem HM, Al-mukhtar AM. Experimental and analytical study of the hyperelastic behavior of the hydrogel under unconfined compression. Procedia Structural Integrity. 2020; 25:3-7.
[Crossref] [Google Scholar]
[32]Liu Y, Moran B. Effects of multiple families of nonlinear fibers on finite deformation near a crack tip in a neo-Hookean sheet. European Journal of Mechanics-A/Solids. 2021; 90:1-19.
[Crossref] [Google Scholar]
[33]Plotnikov PI. Mathematical modeling of neo-Hookean material growth. Doklady Mathematics. 2021; 104(3):380-4. Pleiades Publishing.
[Crossref] [Google Scholar]
[34]Zheng Y, Cai S. Analytical solutions of cavitation instability in a compressible hyperelastic solid. International Journal of Non-Linear Mechanics. 2020; 126(2020):1-6.
[Crossref] [Google Scholar]
[35]Shao Z, Zhu M, Wang H, Li M. Effect of aging of foam rubber on properties and constitutive models. In journal of physics: conference series 2021 (pp. 1-5). IOP Publishing.
[Crossref] [Google Scholar]
[36]https://www.nist.gov/system/files/documents/mml/bbd/biomaterials/Scaffold-Fabrication-Tutorial.pdf. Accessed 26 October 2020.
[37]Thadavirul N, Pavasant P, Supaphol P. Development of polycaprolactone porous scaffolds by combining solvent casting, particulate leaching, and polymer leaching techniques for bone tissue engineering. Journal of Biomedical Materials Research Part A. 2014; 102(10):3379-92.
[Crossref] [Google Scholar]
[38]Phothiphatcha J, Puttapitukporn T. Determination of material parameters of PDMS material models by MATLAB. Engineering Journal. 2021; 25(4):11-28.
[Crossref] [Google Scholar]
[39]Kim B, Lee SB, Lee J, Cho S, Park H, Yeom S, et al. A comparison among neo-Hookean model, mooney-rivlin model, and ogden model for chloroprene rubber. International Journal of Precision Engineering and Manufacturing. 2012; 13(5):759-64.
[Crossref] [Google Scholar]
[40]Ogden RW. Large deformation isotropic elasticity–on the correlation of theory and experiment for incompressible rubberlike solids. Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences. 1972; 326(1567):565-84.
[Crossref] [Google Scholar]
[41]Berselli G, Vertechy R, Pellicciari M, Vassura G. Hyperelastic modeling of rubber-like photopolymers for additive manufacturing processes. Rapid Prototyping Technology-Principles and Functional Requirements, Hoque, M.(Ed.), IntechOpen Ltd., London. 2011:135-52.
[Google Scholar]
[42]Łagan SD, Liber-kneć A. Experimental testing and constitutive modeling of the mechanical properties of the swine skin tissue. ACTA of Bioengineering and Biomechanics. 2017; 19(2):93-102.
[Crossref] [Google Scholar]
[43]Wiwatwongwana F, Klunathon Y, Rangsri W, Promma N, Pattana S. Identification of shear modulus of gelatin blended with carboxymethylcellulose scaffolds using curve fitting method from compressive test. Journal of Materials Science Research. 2012; 1(4):106-13.
[Google Scholar]
[44]Huang Y, Onyeri S, Siewe M, Moshfeghian A, Madihally SV. In vitro characterization of chitosan–gelatin scaffolds for tissue engineering. Biomaterials. 2005; 26(36):7616-27.
[Crossref] [Google Scholar]
[45]Lien SM, Ko LY, Huang TJ. Effect of crosslinking temperature on compression strength of gelatin scaffold for articular cartilage tissue engineering. Materials Science and Engineering: C. 2010; 30(4):631-5.
[Crossref] [Google Scholar]
[46]Harley BA, Leung JH, Silva EC, Gibson LJ. Mechanical characterization of collagen–glycosaminoglycan scaffolds. ACTA Biomaterialia. 2007; 3(4):463-74.
[Crossref] [Google Scholar]